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Article

CcpA Regulates Central Metabolism and Virulence Gene Expression in <i>Streptococcus mutans</i>

26 Jan 2008

Abstract excerpt

CcpA globally regulates transcription in response to carbohydrate availability in many gram-positive bacteria, but its role in Streptococcus mutans remains enigmatic. Using the fructan hydrolase (fruA) gene of S. mutans as a model, we demonstrated that CcpA plays a direct role in carbon catabolite repression (CCR). Subsequently, the expression of 170 genes was shown to be differently expressed (> or = 2-fold) in...

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PMID: 18223086
DOI: 10.1128/jb.01237-07

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