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Article

Lymphotoxin-α 252 A>G polymorphism: a link between disease susceptibility and dyslipidemia in rheumatoid arthritis?

The Journal of rheumatology - 1 Jul 2011

Santos Maria J, Fernandes Diana, Caetano-Lopes Joana, Perpetuo Inês P, Vidal Bruno, Canhao Helena, Fonseca João E

Abstract excerpt

OBJECTIVE: Rheumatoid arthritis (RA) is associated with higher levels of inflammatory mediators and with a more atherogenic lipid profile. Dyslipidemia can be present years before arthritis develops. Lymphotoxin-α (LTA) is a cytokine that mediates proinflammatory responses while also participating in lipid homeostasis, and its transcriptional activity is in part genetically determined. We examined the role of the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 21459939
DOI: 10.3899/jrheum.101170

Genes

LTA
CRP

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