Article
Cysts of PRKCSH mutated polycystic liver disease patients lack hepatocystin but express Sec63p.
Histochemistry and cell biology - 1 Mar 2008
Waanders Esmé, Croes Huib J E, Maass Cathy N, te Morsche René H M, van Geffen Hendrikus J A A, van Krieken J Han J M, Fransen Jack A M, Drenth Joost P H
Abstract excerpt
Polycystic liver disease (PCLD) is an inherited disorder caused by mutations in either PRKCSH (hepatocystin) or SEC63 (Sec63p). However, expression patterns of the implicated proteins in diseased and normal liver are unknown. We analyzed subcellular and cellular localization of hepatocystin and Sec63p using cell fractionation, immunofluorescence, and immunohistochemical methods. Expression patterns were assessed...
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