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Article

Hepatocystin is not secreted in cyst fluid of hepatocystin mutant polycystic liver patients.

Journal of proteome research - 1 Jun 2008

Waanders Esmé, Lameris Anke L L, Op den Camp Huub J M, Pluk Wendy, Gloerich Jolein, Strijk Simon P, Drenth Joost P H

Abstract excerpt

Autosomal dominant polycystic liver disease (PCLD) is characterized by multiple liver cysts and is caused by mutations in PRKCSH (hepatocystin). Mechanisms of cystogenesis are unknown, but previous studies have shown that hepatocystin is secreted in vitro. The goal of this study was to determine the fate of hepatocystin in vivo. Using immunoprecipitation, we determined that mutant hepatocystin is secreted from...

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Source

Identifiers

PMID: 18419150
DOI: 10.1021/pr8000282

Genes

PRKCSH

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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Hepatocystin is not secreted in cyst fluid of hepatocystin mutant polycystic liver patients.PMID 18419150Read ↗

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