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Article

Evidence of major genes effects on serum homocysteine and fibrinogen levels, and premature ischemic heart disease in Italian extended families.

Human heredity - 1 Jan 2008

Grassi Mario, Kisialiou Aliaksei, Assanelli Deodato, Mozzini Chiara, Archetti Silvana, Pezzini Alessandro

Abstract excerpt

OBJECTIVES: The purpose of the present study was to investigate the effect of novel genetic factors on plasma levels of total homocysteine (tHcy) and fibrinogen (FIB). As tHcy and FIB have been consistently associated to increased risk of ischemic heart disease (IHD) and acute myocardial infarction (MI) also genes-trait-MI mediational effects were tested. METHODS: A complex segregation analysis, and a mediation...

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Identifiers

PMID: 18223316
DOI: 10.1159/000114165

Genes

MTHFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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