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Determination of new types of DNA lesions in human sperm

25 Jan 2008

Abstract excerpt

Careful attention has been focused recently on DNA quality in human IVF. Therefore a variety of methods has been developed to evaluate DNA integrity, especially concerning fragmentation. Using liquid chromatography and mass spectrometry (LC/MS/MS) for our best sperm samples, we have established reference values for several oxidative lesions, in order to gain insights into the cause of DNA lesions. Besides...

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PMID: 18221576
DOI: 10.1017/s0967199407004340

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