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In Vitro Analysis of Tobramycin-Treated <i>Pseudomonas aeruginosa</i> Biofilms on Cystic Fibrosis-Derived Airway Epithelial Cells

23 Jan 2008

Abstract excerpt

P. aeruginosa forms biofilms in the lungs of individuals with cystic fibrosis (CF); however, there have been no effective model systems for studying biofilm formation in the CF lung. We have developed a tissue culture system for growth of P. aeruginosa biofilms on CF-derived human airway cells that promotes the formation of highly antibiotic-resistant microcolonies, which produce an extracellular polysaccharide...

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PMID: 18212077
DOI: 10.1128/iai.01373-07

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