Article
The DeltaF508-CFTR mutation results in increased biofilm formation by Pseudomonas aeruginosa by increasing iron availability.
American journal of physiology. Lung cellular and molecular physiology - 1 Jul 2008
Moreau-Marquis Sophie, Bomberger Jennifer M, Anderson Gregory G, Swiatecka-Urban Agnieszka, Ye Siying, O'Toole George A, Stanton Bruce A
Abstract excerpt
Enhanced antibiotic resistance of Pseudomonas aeruginosa in the cystic fibrosis (CF) lung is thought to be due to the formation of biofilms. However, there is no information on the antibiotic resistance of P. aeruginosa biofilms grown on human airway epithelial cells or on the effects of airway cells on biofilm formation by P. aeruginosa. Thus we developed a coculture model and report that airway cells increase...
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