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In Vivo Evidence of <i>Pseudomonas aeruginosa</i> Nutrient Acquisition and Pathogenesis in the Lungs of Cystic Fibrosis Patients

28 Aug 2007

Abstract excerpt

One of the hallmarks of Pseudomonas aeruginosa infection in cystic fibrosis (CF) patients is very-high-cell-density (HCD) replication in the lung, allowing this bacterium to induce virulence controlled by the quorum-sensing systems. However, the nutrient sources sustaining HCD replication in this chronic infection are largely unknown. Here, we performed microarray studies of P. aeruginosa directly isolated from...

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PMID: 17724070
DOI: 10.1128/iai.01807-06

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