Article
The molecular characterization of an A:T to G:C transition in the Hbb-b1 gene of the murine homologue of hemoglobin Rainier.
Biochemical genetics - 1 Dec 1991
Jones J, Peters J
Abstract excerpt
An N-ethyl-N-nitrosourea (ENU)-induced mutation in the Hbb-b1 gene of the mouse hemoglobin-beta complex (Hbb) has been shown to result in a high-oxygen affinity hemoglobin, homologous with hemoglobin Rainier in man (Peters, J., et al., Genetics 110:709, 1985). Substitution of beta 145 tyrosine by cysteine had occurred in both human and mouse forms, probably as the result of a point mutation. Provided that...
Topics
- Alleles
- Animals
- Base Sequence
- Codon
- DNA Mutational Analysis
- Ethylnitrosourea
- Genes
- Globins
- Hemoglobins, Abnormal
- Humans
- Mice
- Mice, Inbred Strains