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Article

Centrosome amplification induced by survivin suppression enhances both chromosome instability and radiosensitivity in glioma cells

1 Jan 2008

Abstract excerpt

Glioblastoma is characterised by invasive growth and a high degree of radioresistance. Survivin, a regulator of chromosome segregation, is highly expressed and known to induce radioresistance in human gliomas. In this study, we examined the effect of survivin suppression on radiosensitivity in malignant glioma cells, while focusing on centrosome aberration and chromosome instability (CIN). We suppressed survivin...

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Identifiers

PMID: 18195712
DOI: 10.1038/sj.bjc.6604160

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