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Article

Misfolding of the cystic fibrosis transmembrane conductance regulator and disease.

Biochemistry - 12 Feb 2008

Cheung Joanne C, Deber Charles M

Abstract excerpt

Understanding the structural basis for defects in protein function that underlie protein-based genetic diseases is the fundamental requirement for development of therapies. This situation is epitomized by the cystic fibrosis transmembrane conductance regulator (CFTR)-the gene product known to be defective in CF patients-that appears particularly susceptible to misfolding when its biogenesis is hampered by...

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Identifiers

PMID: 18193900
DOI: 10.1021/bi702209s

Genes

CFTR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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