Article
An improved human carboxylesterase for enzyme/prodrug therapy with CPT-11.
Cancer gene therapy - 1 Mar 2008
Wierdl M, Tsurkan L, Hyatt J L, Edwards C C, Hatfield M J, Morton C L, Houghton P J, Danks M K, Redinbo M R, Potter P M
Abstract excerpt
CPT-11 is a potent antitumor agent that is activated by carboxylesterases (CE) and intracellular expression of CEs that can activate the drug results in increased cytotoxicity to the drug. As activation of CPT-11 (irinotecan-7-ethyl-10-[4-(1-piperidino)-1-piperidino]carbonyloxycamptothecin) by human CEs is relatively inefficient, we have developed enzyme/prodrug therapy approaches based on the CE/CPT-11...
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