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Inducible Packaging Cells for Large-scale Production of Lentiviral Vectors in Serum-free Suspension Culture

8 Jan 2008

Abstract excerpt

We have developed new packaging cell lines (293SF-PacLV) that can produce lentiviral vectors (LVs) in serum-free suspension cultures. A cell line derived from 293SF cells, expressing the repressor (CymR) of the cumate switch and the reverse transactivator (rtTA2(S)-M2) of the tetracycline (Tet) switch, was established first. We next generated clones stably expressing the Gag/Pol and Rev genes of human...

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PMID: 18180776
DOI: 10.1038/sj.mt.6300383

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