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Article

Opacity factor activity and epithelial cell binding by the serum opacity factor protein of Streptococcus pyogenes are functionally discrete.

The Journal of biological chemistry - 7 Mar 2008

Gillen Christine M, Courtney Harry S, Schulze Kai, Rohde Manfred, Wilson Mark R, Timmer Anjuli M, Guzman Carlos A, Nizet Victor, Chhatwal G S, Walker Mark J

Abstract excerpt

Serum opacity factor (SOF) is a unique multifunctional virulence determinant expressed at the surface of Streptococcus pyogenes and has been shown to elicit protective immunity against GAS infection in a murine challenge model. SOF consists of two distinct domains with different binding capacities: an N-terminal domain that binds apolipoprotein AI and a C-terminal repeat domain that binds fibronectin and...

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PMID: 18180300
DOI: 10.1074/jbc.M706739200

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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