Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Serum opacity factor promotes group A streptococcal epithelial cell invasion and virulence.

Molecular microbiology - 1 Oct 2006

Timmer Anjuli M, Kristian Sascha A, Datta Vivekanand, Jeng Arthur, Gillen Christine M, Walker Mark J, Beall Bernard, Nizet Victor

Abstract excerpt

Serum opacity factor (SOF) is a bifunctional cell surface protein expressed by 40-50% of group A streptococcal (GAS) strains comprised of a C-terminal domain that binds fibronectin and an N-terminal domain that mediates opacification of mammalian sera. The sof gene was recently discovered to be cotranscribed in a two-gene operon with a gene encoding another fibronectin-binding protein, sfbX. We compared the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Carrier Proteins
Share to Cell Line, Tumor

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Epithelial Cells

Share to Fibronectins

Share to Intracellular Signaling Peptides and Proteins

Share to Peptide Hydrolases

Share to Streptococcus pyogenes

Share to Virulence

Source

Identifiers

PMID: 16942605
DOI: 10.1111/j.1365-2958.2006.05337.x

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Serum opacity factor promotes group A streptococcal epithelial cell invasion and virulence.PMID 16942605Read ↗

Molecular Genetic Analysis of a Group A Streptococcus Operon Encoding Serum Opacity Factor and a Novel Fibronectin-Binding Protein, SfbXSemantic proximity Read ↗

Opacity factor activity and epithelial cell binding by the serum opacity factor protein of Streptococcus pyogenes are functionally discrete.Semantic proximity Read ↗

The Structure and Function of Serum Opacity Factor: A Unique Streptococcal Virulence Determinant That Targets High-Density LipoproteinsSemantic proximity Read ↗

Serum Opacity Factor, a Streptococcal Virulence Factor That Binds to Apolipoproteins A-I and A-II and Disrupts High Density Lipoprotein StructureSemantic proximity Read ↗

Identification of a Novel Virulence Determinant with Serum Opacification Activity in<i>Streptococcus suis</i>Semantic proximity Read ↗

Recruitment of Complement Factor H-Like Protein 1 Promotes Intracellular Invasion by Group A StreptococciSemantic proximity Read ↗

Fibronectin-binding protein acts as Staphylococcus aureus invasin via fibronectin bridging to integrin alpha5beta1Semantic proximity Read ↗

The FbaB-type fibronectin-binding protein of Streptococcus pyogenes promotes specific invasion into endothelial cellsSemantic proximity Read ↗

Epithelial cell invasion by group B streptococci is important to virulence.Semantic proximity Read ↗

Identification of a group B streptococcal fibronectin binding protein, SfbA, that contributes to invasion of brain endothelium and development of meningitis.Semantic proximity Read ↗

The extracellular protein factor Epf from Streptococcus pyogenes is a cell surface adhesin that binds to cells through an N-terminal domain containing a carbohydrate-binding module.Semantic proximity Read ↗

A locus of group A streptococcus involved in invasive disease and DNA transferSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.