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Article

Human cytomegalovirus regulates surface expression of the viral protein UL18 by means of two motifs present in the cytoplasmic tail.

Journal of immunology (Baltimore, Md. : 1950) - 15 Jan 2008

Maffei Massimo, Ghiotto Fabio, Occhino Marzia, Bono Maria, De Santanna Amleto, Battini Lorenzo, Gusella G Luca, Fais Franco, Bruno Silvia, Ciccone Ermanno

Abstract excerpt

UL18 is a trans-membrane viral protein expressed on human cytomegalovirus (HCMV)-infected cells, and its surface expression determines the interaction of infected cells with lymphocytes expressing the CD85j (LIR-1/ILT2) receptor. We previously showed that the UL18-CD85j interaction elicits activation of T lymphocytes. However, in in vitro cell models UL18 displays mostly undetectable surface expression. Thus, we...

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PMID: 18178837
DOI: 10.4049/jimmunol.180.2.969

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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