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Toxoplasma gondii and Cryptosporidium parvum Lack Detectable DNA Cytosine Methylation

5 Jan 2008

Abstract excerpt

Epigenetic factors play a role in the expression of virulence traits in Apicomplexa. Apicomplexan genomes encode putative DNA cytosine methylation enzymes. To assess the presence of cytosine methylation of Toxoplasma gondii and Cryptosporidium parvum DNA, we used mass spectrometry analysis and confirmed that these organisms lack detectable methylcytosine in their DNA.

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PMID: 18178772
DOI: 10.1128/ec.00448-07

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