Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

FRS2 alpha 2F/2F mice lack carotid body and exhibit abnormalities of the superior cervical sympathetic ganglion and carotid sinus nerve.

Developmental biology - 1 Feb 2008

Kameda Yoko, Ito Masataka, Nishimaki Toshiyuki, Gotoh Noriko

Abstract excerpt

The docking protein FRS2 alpha is an important mediator of fibroblast growth factor (FGF)-induced signal transduction, and functions by linking FGF receptors (FGFRs) to a variety of intracellular signaling pathways. We show that the carotid body is absent in FRS2 alpha(2F/2F) mice, in which the Shp2-binding sites of FRS2 alpha are disrupted. We also show that the carotid body rudiment is not formed in the wall of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Carotid Artery, Common
Share to Membrane Proteins

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Mice, Mutant Strains

Share to Mutation

Share to Nerve Fibers

Source

Identifiers

PMID: 18177855
DOI: 10.1016/j.ydbio.2007.12.002

Genes

FRS2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

FRS2 alpha 2F/2F mice lack carotid body and exhibit abnormalities of the superior cervical sympathetic ganglion and carotid sinus nerve.PMID 18177855Read ↗

FRS2alpha is required for the separation, migration, and survival of pharyngeal-endoderm derived organs including thyroid, ultimobranchial body, parathyroid, and thymus.Semantic proximity Read ↗

The ErbB2 and ErbB3 receptors and their ligand, neuregulin-1, are essential for development of the sympathetic nervous system.Semantic proximity Read ↗

Abnormalities in pharyngeal arch-derived structures in SATB2-associated syndrome.Semantic proximity Read ↗

<i>Phox2b</i>controls the development of peripheral chemoreceptors and afferent visceral pathwaysSemantic proximity Read ↗

Tyrosine phosphorylation sites on FRS2alpha responsible for Shp2 recruitment are critical for induction of lens and retina.Semantic proximity Read ↗

Dual role for neural crest cells during outflow tract septation in the neural crest-deficient mutant Splotch(2H).Semantic proximity Read ↗

Disruption of the Hoxa3 homeobox gene results in anomalies of the carotid artery system and the arterial baroreceptors.Semantic proximity Read ↗

GFR alpha3, a component of the artemin receptor, is required for migration and survival of the superior cervical ganglion.Semantic proximity Read ↗

Sprouty genes are essential for the normal development of epibranchial ganglia in the mouse embryo.Semantic proximity Read ↗

Altered neuronal lineages in the facial ganglia of Hoxa2 mutant mice.Semantic proximity Read ↗

Impaired posterior frontal sutural fusion in the biglycan/decorin double deficient mice.Semantic proximity Read ↗

G-Protein α-Subunit Gsα Is Required for Craniofacial Morphogenesis.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.