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Article

A geographic variant of the Staphylococcus aureus Panton-Valentine leukocidin toxin and the origin of community-associated methicillin-resistant S. aureus USA300.

The Journal of infectious diseases - 15 Jan 2008

O'Hara F Patrick, Guex Nicolas, Word J Michael, Miller Linda A, Becker Julie A, Walsh Stacey L, Scangarella Nicole E, West Joshua M, Shawar Ribhi M, Amrine-Madsen Heather

Abstract excerpt

BACKGROUND: The majority of recent community-associated methicillin-resistant Staphylococcus aureus (MRSA) infections in the United States have been caused by a single clone, USA300. USA300 secretes Panton-Valentine leukocidin (PVL) toxin, which is associated with highly virulent infections. METHODS: We sequenced the PVL genes of 174 S. aureus isolates from a global clinical sample. We combined phylogenetic...

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Identifiers

PMID: 18177252
DOI: 10.1086/524684

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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