Article
Origin, evolution, and global transmission of community-acquired Staphylococcus aureus ST8.
Proceedings of the National Academy of Sciences of the United States of America - 5 Dec 2017
Strauß Lena, Stegger Marc, Akpaka Patrick Eberechi, Alabi Abraham, Breurec Sebastien, Coombs Geoffrey, Egyir Beverly, Larsen Anders Rhod, Laurent Frederic, Monecke Stefan, Peters Georg, Skov Robert, Strommenger Birgit, Vandenesch François, Schaumburg Frieder, Mellmann Alexander
Abstract excerpt
USA300 is a pandemic clonal lineage of hypervirulent, community-acquired, methicillin-resistant Staphylococcus aureus (CA-MRSA) with specific molecular characteristics. Despite its high clinical relevance, the evolutionary origin of USA300 remained unclear. We used comparative genomics of 224 temporal and spatial diverse S. aureus isolates of multilocus sequence type (ST) 8 to reconstruct the molecular evolution...
Topics
- Africa
- Australia
- Bacterial Toxins
- Bayes Theorem
- Community-Acquired Infections
- Europe
- Evolution, Molecular
- Exotoxins
- Genome, Bacterial