Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Chemical Attenuation of Plasmodium berghei Sporozoites Induces Sterile Immunity in Mice

4 Jan 2008

Abstract excerpt

Radiation and genetic attenuation of Plasmodium sporozoites are two approaches for whole-organism vaccines that protect against malaria. We evaluated chemical attenuation of sporozoites as an alternative vaccine strategy. Sporozoites were treated with the DNA sequence-specific alkylating agent centanamycin, a compound that significantly affects blood stage parasitemia and transmission of murine malaria and also...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Malaria Research and Control
Share to Mosquito-borne diseases and control
Share to Parasites and Host Interactions

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 18174336
DOI: 10.1128/iai.01399-07

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Chemical Attenuation of Plasmodium berghei Sporozoites Induces Sterile Immunity in MicePMID 18174336Read ↗

A replication competent Plasmodium falciparum parasite completely attenuated by dual gene deletionSemantic proximity Read ↗

Creation and preclinical evaluation of genetically attenuated malaria parasites arresting growth late in the liverSemantic proximity Read ↗

Chemovaccination with a novel antimalarial targeting the late liver stage induces durable immunity against malariaSemantic proximity Read ↗

Genetically modified Plasmodium parasites as a protective experimental malaria vaccine.Semantic proximity Read ↗

Conserved Protective Mechanisms in Radiation and Genetically Attenuated uis3(-) and uis4(-) Plasmodium SporozoitesSemantic proximity Read ↗

Designer Parasites: Genetically Engineered Plasmodium as Vaccines To Prevent Malaria InfectionSemantic proximity Read ↗

A replication-competent late liver stage–attenuated human malaria parasiteSemantic proximity Read ↗

Extreme CD8 T Cell Requirements for Anti-Malarial Liver-Stage Immunity following Immunization with Radiation Attenuated SporozoitesSemantic proximity Read ↗

Genetically Attenuated Plasmodium berghei Liver Stages Persist and Elicit Sterile Protection Primarily via CD8 T CellsSemantic proximity Read ↗

Class II-Restricted Protective Immunity Induced by Malaria SporozoitesSemantic proximity Read ↗

Chemically attenuated Plasmodium sporozoites induce specific immune responses, sterile immunity and cross-protection against heterologous challengeSemantic proximity Read ↗

Genetically engineered, attenuated whole-cell vaccine approaches for malariaSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.