Article
Characterization of CD4+ FOXP3+ T-cell clones established from chronic inflammatory lesions.
Oral microbiology and immunology - 1 Feb 2008
Okui T, Ito H, Honda T, Amanuma R, Yoshie H, Yamazaki K
Abstract excerpt
INTRODUCTION: Our previous study demonstrated that the gene expression of FOXP3, a characteristic marker for CD4(+) CD25(+) regulatory T cells in mice, is upregulated more in periodontitis than in gingivitis at the messenger RNA (mRNA) level. Furthermore, most of the T-cell clones established from periodontitis lesions expressed FOXP3 mRNA. However, role of the FOXP3(+) gingival T cells has not been elucidated....
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