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Article

Cyclooxygenase-2 Gene-765 single nucleotide polymorphism as a protective factor against periodontitis in Taiwanese.

Journal of clinical periodontology - 1 Jan 2008

Ho Ya-Ping, Lin Ying-Chu, Yang Yi-Hsin, Ho Kun-Yen, Wu Yi-Min, Tsai Chi-Cheng

Abstract excerpt

AIM: Prostaglandin E(2) (PGE(2)) is considered to be an important mediator of tissue destruction in periodontitis. The cyclooxygenase (COX) catalyses the production of PGs. COX-2, which is induced in an inflammatory response, is responsible for PGs synthesis at sites of inflammation. A single nucleotide polymorphism of COX-2(-765) has been shown to alter the expression of the COX-2 gene. The purpose of the...

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Identifiers

PMID: 18173398
DOI: 10.1111/j.1600-051X.2007.01167.x

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