Identification of Patients with (Atypical) <i>MUTYH</i>-Associated Polyposis by <i>KRAS2</i> c.34G &amp;gt; T Prescreening Followed by <i>MUTYH</i> Hotspot Analysis in Formalin-Fixed Paraffin-Embedded Tissue

Abstract excerpt

PURPOSE: To assess the feasibility of identifying patients with (atypical) MUTYH-associated polyposis (MAP) by KRAS2 c.34G > T prescreening followed by MUTYH hotspot mutation analysis in formalin-fixed paraffin-embedded tissue (FFPE). METHODS: We collected 210 colorectal FFPE tumors from 192 individuals who presented with <10 adenomas or familial mismatch repair proficient colorectal carcinomas with <10...

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