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Article

Somatic c.34G>T KRAS mutation: a new prescreening test for MUTYH-associated polyposis?

Cancer genetics - 1 Jan 2000

Aimé Adeline, Coulet Florence, Lefevre Jeremie H, Colas Chrystelle, Cervera Pascale, Flejou Jean-François, Lascols Olivier, Soubrier Florent, Parc Yann

Abstract excerpt

We investigated the somatic c.34G>T KRAS transversion as a marker suggestive of MUTYH-associated polyposis (MAP). We compared 86 adenomas and 19 colorectal cancers (CRCs) of 30 MAP patients to 135 adenomas and five CRCs of 47 familial adenomatous polyposis (FAP) patients. The c.34G>T mutation was investigated by DNA sequencing. Secondly, the germline MUTYH gene sequence was analyzed in patients carrying c.34G>T...

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Source

Identifiers

PMID: 26056087
DOI: 10.1016/j.cancergen.2015.04.005

Genes

MUTYH
KRAS
FAP
APC

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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