Article
Sequence variation occurs in CD4 epitopes during early HIV infection.
Journal of acquired immune deficiency syndromes (1999) - 1 Nov 2007
Rychert Jenna, Saindon Suzanne, Placek Sarah, Daskalakis Demetre, Rosenberg Eric
Abstract excerpt
OBJECTIVE: To determine whether viral sequence variation occurs in HIV-specific CD4 epitopes during early HIV infection. METHODS: Gag, Nef, and integrase (Int) sequences were obtained from the plasma of 7 subjects identified during acute HIV-1 infection. Changes in the viral sequence were determined based on comparison of sequences obtained at 2 time points during early infection. Peptide-specific CD4+ T-cell...
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