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Article

Prematuration of human denuded oocytes in a three-dimensional co-culture system: effects on meiosis progression and developmental competence

4 Dec 2008

Abstract excerpt

BACKGROUND: During conventional in vitro maturation (IVM), oocytes undergo nuclear maturation but do not attain full cytoplasmic maturity. The present study aimed to evaluate the quality of denuded in vitro matured human oocytes (= 'rescue IVM') following a prematuration culture (PMC) in a three-dimensional (3D) co-culture system with cumulus cells. METHODS: Denuded, germinal vesicle (GV) oocytes retrieved from...

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PMID: 19056772
DOI: 10.1093/humrep/den420

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