Determination of Accessory Gene Patterns Predicts the Same Relatedness among Strains of <i>Streptococcus pneumoniae</i> as Sequencing of Housekeeping Genes Does and Represents a Novel Approach in Molecular Epidemiology

Abstract excerpt

Relatedness between isolates of Streptococcus pneumoniae can be determined from sequences of multiple genes belonging to the core genome (multilocus sequence typing [MLST]), but these do not provide information on gene content that may affect the potential of isolates to cause invasive pneumococcal disease. Gene content data, obtained using microarrays, were gathered for 40 clinical isolates of 12 serotypes...

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