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Article

The CCR2 promoter polymorphism T-960A, but not the serum MCP-1 level, is associated with endothelial function in prediabetic individuals.

Atherosclerosis - 1 Jun 2008

Rittig Kilian, Peter Andreas, Baltz Katrin M, Tschritter Otto, Weigert Cora, Andreozzi Francesco, Perticone Francesco, Siegel-Axel Dorothea I, Stefan Norbert, Fritsche Andreas, Salih Helmut R, Schleicher Erwin, Machicao Fausto, Sesti Giorgio, Häring Hans-Ulrich, Balletshofer Bernd M

Abstract excerpt

Monocyte-chemoattractant-protein (MCP)-1 and its receptor CCR2 have been shown to play a pivotal role in vascular inflammation and atherosclerotic plaque formation. However, it is currently unclear whether MCP-1/CCR2 triggered inflammation affects nitric oxide (NO)-bioavailability, hence influencing vascular function, a sign of early atherosclerosis. Therefore, we sought to investigate the association between...

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Source

Identifiers

PMID: 18096169
DOI: 10.1016/j.atherosclerosis.2007.10.028

Genes

CCR2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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