Article
Polymorphism of the monocyte chemoattractant protein (MCP-1) gene is associated with the plasma level of MCP-1 but not with carotid intima-media thickness.
Hypertension research : official journal of the Japanese Society of Hypertension - 1 Sept 2003
Tabara Yasuharu, Kohara Katsuhiko, Yamamoto Yoshikuni, Igase Michiya, Nakura Jun, Kondo Ikuko, Miki Tetsuro
Abstract excerpt
Monocyte chemoattractant protein-1 (MCP-1) plays an important role in atherosclerosis. Recently, single nucleotide polymorphisms (SNPs) in the MCP-1 regulatory region have been identified, and an in vitro study demonstrated that the SNP at position -2518 of the MCP-1 gene affected transcription of the gene. The purpose of this study was to clarify the association of the plasma level of MCP-1 and the SNP of the...
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