Article
[JAK2(V617F) mutation in Korean patients with essential thrombocythemia].
The Korean journal of laboratory medicine - 1 Apr 2007
Ahn Jeong Yeal, Yoo Soo Jin, Bang Soo Mee, Park Pil Whan, Seo Yiel Hea, Shin Dong Bok, Lee Jae Hoon
Abstract excerpt
BACKGROUND: Essential thrombocythemia (ET) is thought to reflect transformation of a multipotent hematopoietic stem cell, but its molecular pathogenesis remains obscure. But tyrosine kinase, especially Janus kinase 2 (JAK2), has been implicated in myeloproliferative disorders other than chronic myeloid leukemia. We investigated the frequency of JAK2 mutation and its correlation with other clinicopathologic...
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