Article
A single-amino-acid substitution in the TvbS1 receptor results in decreased susceptibility to infection by avian sarcoma and leukosis virus subgroups B and D and resistance to infection by subgroup E in vitro and in vivo.
Journal of virology - 1 Mar 2008
Reinisová Markéta, Senigl Filip, Yin Xueqian, Plachy Jirí, Geryk Josef, Elleder Daniel, Svoboda Jan, Federspiel Mark J, Hejnar Jirí
Abstract excerpt
The avian sarcoma and leukosis virus (ASLV) family of retroviruses contains five highly related envelope subgroups (A to E) thought to have evolved from a common viral ancestor in the chicken population. Three genetic loci in chickens determine the susceptibility or resistance of cells to infection by the subgroup A to E ASLVs. Some inbred lines of chickens display phenotypes that are somewhere in between either...
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