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Structure of Antibody-Neutralized Murine Norovirus and Unexpected Differences from Viruslike Particles

20 Dec 2007

Abstract excerpt

Noroviruses (family Caliciviridae) are the major cause of epidemic nonbacterial gastroenteritis in humans, but the mechanism of antibody neutralization is unknown and no structure of an infectious virion has been reported. Murine norovirus (MNV) is the only norovirus that can be grown in tissue culture, studied in an animal model, and reverse engineered via an infectious clone and to which neutralizing antibodies...

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PMID: 18094184
DOI: 10.1128/jvi.02200-07

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