Article
Mutations in the voltage-gated sodium channel gene of anophelines and their association with resistance to pyrethroids - a review.
Parasites & vectors - 7 Oct 2014
Silva Ana Paula B, Santos Joselita Maria M, Martins Ademir J
Abstract excerpt
Constant and extensive use of chemical insecticides has created a selection pressure and favored resistance development in many insect species worldwide. One of the most important pyrethroid resistance mechanisms is classified as target site insensitivity, due to conformational changes in the target site that impair a proper binding of the insecticide molecule. The voltage-gated sodium channel (NaV) is the target...
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