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Article

Efavirenz pharmacokinetics in HIV-1-infected children are associated with CYP2B6-G516T polymorphism.

Journal of acquired immune deficiency syndromes (1999) - 1 Jul 2007

Saitoh Akihiko, Fletcher Courtney V, Brundage Richard, Alvero Carmelita, Fenton Terrence, Hsia Karen, Spector Stephen A

Abstract excerpt

BACKGROUND: The CYP2B6-G516T polymorphism has been shown to alter plasma efavirenz (EFV) concentrations in adults. The impact of CYP2B6-G516T polymorphisms on EFV concentrations may be different in children because of differences in liver maturation and drug dosage. METHODS: The CYP2B6-G516T poly...

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Identifiers

PMID: 17356468
DOI: 10.1097/QAI.0b013e318040b29e

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-17356468-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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