Article
Aberrant fibrillin-1 expression in early emphysematous human lung: a proposed predisposition for emphysema.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc - 1 Mar 2008
Robbesom Antoine A, Koenders Mieke M J F, Smits Nicole C, Hafmans Theo, Versteeg Elly M M, Bulten Johan, Veerkamp Jacques H, Dekhuijzen P N Richard, van Kuppevelt Toin H
Abstract excerpt
Parenchymal destruction, airspace enlargement, and loss of elasticity are hallmarks of pulmonary emphysema. Although the basic mechanism is unknown, there is a consensus that malfunctioning of the extracellular matrix is a major contributor to the pathogenesis of emphysema. In this study, we analyzed the expression of the elastic fiber protein fibrillin-1 in a large number (n=69) of human lung specimens with...
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