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Article

Filamin A Mutations: A New Cause of Unexplained Emphysema in Adults?

Chest - 1 Mar 2021

Valentin Victor, Bervar Jean-François, Vincent-Delorme Catherine, Smol Thomas, Wemeau Lidwine, Remy Martine, Le Rouzic Olivier, Chenivesse Cécile

Abstract excerpt

Emphysema is a chronic respiratory disorder characterized by destruction of alveoli, usually due to cigarette smoking or exposure to noxious particles or gases. Dysfunction of proteins that are involved in lung development and maintenance, such as alpha-1 antitrypsin, also contributes to emphysema. Filamin A (FLNA) is an actin-binding protein involved in cytoskeleton reorganization. Mutations in the FLNA gene...

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Identifiers

PMID: 33678279
DOI: 10.1016/j.chest.2020.10.003

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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