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Article

Reactivation of gammaHV68 induces neointimal lesions in pulmonary arteries of S100A4/Mts1-overexpressing mice in association with degradation of elastin.

American journal of physiology. Lung cellular and molecular physiology - 1 Feb 2008

Spiekerkoetter Edda, Alvira Cristina Maria, Kim Yu-Mee, Bruneau Alexandra, Pricola Katie Lynn, Wang Lingli, Ambartsumian Noona, Rabinovitch Marlene

Abstract excerpt

S100A4/Mts-overexpressing mice have thick elastic laminae and mild pulmonary arterial hypertension (PAH), and the occasional older mouse develops occlusive neointimal lesions and perivascular inflammation. We hypothesized that a vasculotropic virus could induce neointimal lesions in the S100A4/Mt...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 18083765
DOI: 10.1152/ajplung.00414.2007

Genes

PAH

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-18083765-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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