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Article

Hydrophobic substitutions in the first residue of the CRAC segment of the gp41 protein of HIV.

Biochemistry - 8 Jan 2008

Vishwanathan Sundaram A, Thomas Annick, Brasseur Robert, Epand Raquel F, Hunter Eric, Epand Richard M

Abstract excerpt

We investigated the peptides N-acetyl-AWYIK-amide and N-acetyl-VWYIK-amide corresponding to single amino acid substitutions in LWYIK, a segment found in the gp41 protein of HIV and believed to play a role in sequestering this protein to a cholesterol-rich domain in the membrane. The effects of these peptides on the thermotropic phase transitions of 1-stearoyl-2-oleoylphosphatidylcholine (SOPC) and mixtures of...

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PMID: 18081318
DOI: 10.1021/bi7018892

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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