Article
Association of the mutation for the human carboxypeptidase E gene exon 4 with the severity of coronary artery atherosclerosis.
Molecular biology reports - 1 Feb 2009
Jia En-Zhi, Wang Jie, Yang Zhi-Jian, Zhu Tie-Bing, Wang Lian-Sheng, Wang Hui, Li Chun-Jian, Chen Bo, Cao Ke-Jiang, Huang Jun, Ma Wen-Zhu
Abstract excerpt
OBJECTIVE: To test the hypothesis that the identification of mutation in the carboxypeptidase E (CPE) gene which leads to marked hyperproinsulinaemia is consistent with a possible role for mutations in CPE in the development of coronary atherosclerosis. METHODS: The study subjects consisted of 1084 consecutive patients (812 males and 272 females) who will undergo coronary angiography. The severity of coronary...
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