Article
The HcaR regulatory protein of Photorhabdus luminescens affects the production of proteins involved in oxidative stress and toxemia.
Proteomics - 1 Dec 2007
Chalabaev Sabina, Turlin Evelyne, Charles Jean-François, Namane Abdelkader, Pagès Sylvie, Givaudan Alain, Brito-Fravallo Emma, Danchin Antoine, Biville Francis
Abstract excerpt
Comparison of the proteomes of wild-type Photorhabdus luminescens and its hcaR derivative, grown in insect hemolymph, showed that hcaR disruption decreased the production of toxins (tcdA1, mcf, and pirAB) and proteins involved in oxidative stress response (SodA, AhpC, Gor). The disruption of hcaR did not affect growth rate in insects, but did delay the virulence of P. luminescens in Bombyx mori and Spodoptera...
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