Article
The PhoP-PhoQ two-component regulatory system of Photorhabdus luminescens is essential for virulence in insects.
Journal of bacteriology - 1 Mar 2004
Derzelle Sylviane, Turlin Evelyne, Duchaud Eric, Pages Sylvie, Kunst Frank, Givaudan Alain, Danchin Antoine
Abstract excerpt
Photorhabdus luminescens is a symbiont of entomopathogenic nematodes. Analysis of the genome sequence of this organism revealed a homologue of PhoP-PhoQ, a two-component system associated with virulence in intracellular bacterial pathogens. This organism was shown to respond to the availability of environmental magnesium. A mutant with a knockout mutation in the regulatory component of this system (phoP) had no...
Topics
- Amino Acid Sequence
- Animals
- Bacterial Proteins
- Base Sequence
- Gene Expression Regulation, Bacterial
- Larva
- Magnesium
- Molecular Sequence Data
- Mutation
- Photorhabdus
- Sequence Analysis, DNA
- Signal Transduction
- Spodoptera
- Virulence