Article
An antimicrobial peptide-resistant minor subpopulation of Photorhabdus luminescens is responsible for virulence.
Scientific reports - 2 Mar 2017
Mouammine Annabelle, Pages Sylvie, Lanois Anne, Gaudriault Sophie, Jubelin Gregory, Bonabaud Maurine, Cruveiller Stéphane, Dubois Emeric, Roche David, Legrand Ludovic, Brillard Julien, Givaudan Alain
Abstract excerpt
Some of the bacterial cells in isogenic populations behave differently from others. We describe here how a new type of phenotypic heterogeneity relating to resistance to cationic antimicrobial peptides (CAMPs) is determinant for the pathogenic infection process of the entomopathogenic bacterium Photorhabdus luminescens. We demonstrate that the resistant subpopulation, which accounts for only 0.5% of the wild-type...
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