Article
Prevalence of and molecular basis for tuberculosis drug resistance in the Republic of Georgia: validation of a QIAplex system for detection of drug resistance-related mutations.
Antimicrobial agents and chemotherapy - 1 Feb 2008
Gegia Medea, Mdivani Nino, Mendes Rodrigo E, Li Haijing, Akhalaia Maka, Han Jian, Khechinashvili George, Tang Yi-Wei
Abstract excerpt
We developed a QIAplex system for the simultaneous detection of 24 Mycobacterium tuberculosis gene mutations responsible for resistance to isoniazid (INH), rifampin (RIF), streptomycin (STM), and ethambutol (EMB) in 196 M. tuberculosis isolates recovered in the Republic of Georgia. In comparison to phenotypic susceptibility tests, the QIAplex showed sensitivity and specificity of 85.4% and 96.1% for INH, 94.4%...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.