Article
Determination of ancestral allele for possible human cancer-associated polymorphisms.
Cancer genetics and cytogenetics - 1 Jan 2008
Maruta Yuichi, Okayama Naoko, Hiura Mikako, Suehiro Yutaka, Hirai Hirohisa, Hinoda Yuji
Abstract excerpt
To determine ancestral allele in possible cancer-associated polymorphisms, DNA samples from 10 chimpanzees (Pan troglodytes) were sequenced for alleles corresponding to 17 polymorphisms: 8 short tandem repeats [IL1RN (alias IL-1RA) variable number tandem repeat (VNTR); TYMS (previously TS) VNTR; AR CAG repeat; dinucleotide repeats of UGT1A1, IGF1, IFNG (alias IFN-gamma), ESR1 (alias ER-alpha), and EGFR] and 9...
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