Article
Inadequate inhibition of host RNA polymerase restricts T7 bacteriophage growth on hosts overexpressing udk.
Molecular microbiology - 1 Jan 2008
Qimron Udi, Kulczyk Arkadiusz W, Hamdan Samir M, Tabor Stanley, Richardson Charles C
Abstract excerpt
Overexpression of udk, an Escherichia coli gene encoding a uridine/cytidine kinase, interferes with T7 bacteriophage growth. We show here that inhibition of T7 phage growth by udk overexpression can be overcome by inhibition of host RNA polymerase. Overexpression of gene 2, whose product inhibits host RNA polymerase, restores T7 phage growth on hosts overexpressing udk. In addition, rifampicin, an inhibitor of...
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