Article
Dual-probe system using pyrenylmethyl-modified amino-LNA for mismatch detection.
Nucleosides, nucleotides & nucleic acids - 1 Jan 2007
Umemoto Tadashi, Hrdlicka Patrick J, Babu B Ravindra, Wengel Jesper
Abstract excerpt
A dual-probe containing pyrenylmethyl amino-LNA has been developed for sensitive mismatch detection. While hybridization with complementary DNA/RNA results in very strong excimer signals, exposure to singly mismatched DNA/RNA targets results in significantly decreased excimer emission.
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