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Article

C-terminal PAL motif of presenilin and presenilin homologues required for normal active site conformation.

Journal of neurochemistry - 1 Jan 2006

Wang Jun, Beher Dirk, Nyborg Andrew C, Shearman Mark S, Golde Todd E, Goate Alison

Abstract excerpt

The Alzheimer's disease-associated beta-amyloid peptide is produced through cleavage of amyloid precursor protein by beta-secretase and gamma-secretase. gamma-Secretase is a complex containing presenilin (PS) as the catalytic component and three essential cofactors: Nicastrin, anterior pharynx defective (APH-1) and presenilin enhancer-2 (PEN-2). PS and signal peptide peptidase (SPP) define a novel family of...

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PMID: 16305624
DOI: 10.1111/j.1471-4159.2005.03548.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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C-terminal PAL motif of presenilin and presenilin homologues required for normal active site conformation.PMID 16305624Read ↗

The C-terminal PAL motif and transmembrane domain 9 of presenilin 1 are involved in the formation of the catalytic pore of the gamma-secretase.Semantic proximity Read ↗

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Presenilin transmembrane domain 8 conserved AXXXAXXXG motifs are required for the activity of the γ-secretase complex.Semantic proximity Read ↗

Important functional role of residue x of the presenilin GxGD protease active site motif for APP substrate cleavage specificity and substrate selectivity of γ-secretase.Semantic proximity Read ↗

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Identification of a novel family of presenilin homologues.Semantic proximity Read ↗

A presenilin-1 mutation identified in familial Alzheimer disease with cotton wool plaques causes a nearly complete loss of gamma-secretase activity.Semantic proximity Read ↗

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