Article
Amyotrophic lateral sclerosis: an emerging era of collaborative gene discovery.
PloS one - 5 Dec 2007
Gwinn Katrina, Corriveau Roderick A, Mitsumoto Hiroshi, Bednarz Kate, Brown Robert H, Cudkowicz Merit, Gordon Paul H, Hardy John, Kasarskis Edward J, Kaufmann Petra, Miller Robert, Sorenson Eric, Tandan Rup, Traynor Bryan J, Nash Josefina, Sherman Alex, Mailman Matthew D, Ostell James, Bruijn Lucie, Cwik Valerie, Rich Stephen S, Singleton Andrew, Refolo Larry, Andrews Jaime, Zhang Ran, Conwit Robin, Keller Margaret A
Abstract excerpt
Amyotrophic lateral sclerosis (ALS) is the most common form of motor neuron disease (MND). It is currently incurable and treatment is largely limited to supportive care. Family history is associated with an increased risk of ALS, and many Mendelian causes have been discovered. However, most forms of the disease are not obviously familial. Recent advances in human genetics have enabled genome-wide analyses of...
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